cxcr4/cxcl12 in non-small-cell lung cancer metastasis to the brain

 

 

 

 

Vol 14: CXCR4/CXCL12 in Non-Small-Cell Lung Cancer Metastasis to the Brain.Vol 9: CXCL12 Chemokine Expression Suppresses Human Pancreatic Cancer Growth and Metastasis. Abbreviations: NSCLC, non-small cell lung cancer OR, odds ratio CXCR4, chemokine receptor type 4.Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines. brain metastases chemokines CXCL12 CXCR4 lung cancer metastasis.This review will focus on the emerging data supporting the putative involvement of the CXCR4/CXCL12 signaling axis in non-small-cell lung cancer (NSCLC) metastasis to the brain. CXCR4/CXCL12 axis in non-small cell lung cancer (NSCLC) pathologic roles and therapeutic potential.CXCL12 and CXCR4 in adenocarcinoma of the lung: association with metastasis and survival. Objectives. Although the chemokine CXCL12 and its receptor CXCR4 have been implicated in metastasis of nonsmall cell lung carcinoma, the prognostic significance of these molecules is poorly defined. Additionally, CXCR4 expression in tumor cells was associated with metastasis of many human malignancies (Muller et al 2001 Ben-Baruch, 2008 Zlotnik, 2008(2013). Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells. "The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44"."Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties". Chemokines have been implicated as key contributors of nonsmall cell lung cancer (NSCLC) metastasis. However, the role of CXCR7, a recently discovered receptor for CXCL12 ligand, in the pathogenesis of NSCLC is unknown. Background: This study investigated the correlations between CXCR4 and VEGF-C expression and lymph node metastasis in non-small cell lung cancer (NSCLC). Methods: Tumor specimens, lymph nodes CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells.

Choi YH, Burdick MD, Strieter BA, Mehrad B, Strieter RM.PMID 12692554. Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain. Non-small cell lung cancer Pancreatic cancer. HCQ (prior to surgery).Thus, CQ could be useful to block cancer stem cell-metastasis and may be com-bined with other anti- cancer agents (e.g. gemcitabine) that target the bulk of the tumour [83]. Cancer cell metastasis is affected by the surrounding tumor microenvironments. Metastatic lung cancer cells appear to be able to detect alterations in the environmental cues, so that they successfully migrate to target organs and settle properly [29, 30]. Non-small-cell lung carcinomas (NSCLC) In non-small cell lung cancer, CXCL12 was found to induce tumor cell migration mediated by activation of PI-3 kinaseThe highest levels of expression of CXCL12 were found to occur in lymph nodes, lung, liver, and bone marrow, corresponding to the typical sites of breast cancer metastasis. Another enigma is the selection of metastatic sites: in general lung, cancer cells prefer the lung, brain, bones, and adrenal glands, and within lung carcinoma types, small cellADAM9 regulates lung cancer metastasis to the brain by facilitating the tPA-mediated cleavage of CDCP1 [ 106 ]. Small Cell Lung Cancer. Apoptosis.BACKGROUND: The CXCL12/CXCR4 pathway regulates tumor cell proliferation, metastasis, angiogenesis and the tumor-microenvironment cross-talk in several solid tumors, including glioblastoma (GBM), the most common and fatal brain cancer. We investigated the correlation of these chemokine expressions to prognosis in lymph-node-positive non-small-cell lung cancer (NSCLC) patients. A total of 140 surgically resected specimens of primary site (PS) and metastatic lymph nodes (MLN) This review will focus on the emerging data supporting the putative involvement of the CXCR4/CXCL12 signaling axis in non-small-cell lung cancer (NSCLC) metastasis to the brain.

Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain. Clin Exp Metastasis. 201027:97105.PubMedGoogle Scholar.CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells. Mol Cancer Res. Targeting CSCs and non-CSCs with specific compounds may be an effective approach to reduce lung cancer growth and metastasis.Is the Subject Area "Non-small cell lung cancer" applicable to this article? Description. Lung Cancer (2005) 47, 291—292 LETTER Cytokines in non-sm metastase Sir, We read w jard et a 305 non-sm and witho four stati brain met adenocarc some pred understan of Cell Adhesion in Tumor Progression Metastasis. page 7.Non-hemato poietic tumors including breast, colorectal, melanoma, osteosarcoma, ovarian, pancrea tic, prostate, and small cell lung cancer have all been shown to express CXCR4 and/or respond to CXCL12.The expression of Clinical Colorectal Cancer, Vol. 8, No. 2, 100-105, 2009 Possibly risk factors of Brain Metastasis in Colorectal cancer The majority of patients with brain metastases had concomitant systemic metastases, especially to lung (72.2 with lung metastases) In this study, we constructed a functional CXCL12/CXCR4 autocrine loop in A549 cells using a gene transfection technique to evaluate its effect on the metastasis of non-small cell lung cancer (NSCLC). In small cell lung cancer cells (SCLC)It was recently shown, that immunodeficient mice inoculated with CXCR4-positive human NSCLC had significantly lower organ-specific metastasis while they were injected by antibodies against CXCL12 in non-small-cell lung cancer in vivo models [61-63]. Non-small cell lung cancer (NSCLC) represents about 85 of all lung cancer.Chemokines are expressed in a tissue-specific manner and, concomitant with the most frequent areas of metastasis in lung cancer, CXCL12 is most highly expressed in bone marrow, liver, lung, and brain [6]. The axis of The chemokine CXCL12, which is the sole ligand of CXCR4, is highly expressed in primary lung cancer as well as in the bone marrow, liver, adrenal glands and brain, which are all sites for lung cancer metastasis.Carcinoma, Non-Small-Cell Lung/drug therapy. Key Words : Non-small cell lung carcinoma CXCR4 receptors Metastasis. Non-small cell lung cancer (NSCLC) is the main contributor to cancer-related mortality in Asian and Western populations. Association of CXCR4 Expression with Metastasis and Survival among Patients with Non-small Cell Lung Cancer. Korean J Pathol 2008 42: 358-364. with brain-specific metastasis of non-small cell lung cancer.CXCL12/CXCR4 axis: role in non-small cell lung cancer tumor proliferation. Keywords: Non-small cell lung cancer, brain metastasis, RNAi screening, epigenetics, SIRT1. Introduction Brain metastases are a frequent and ongoing major complication of non-small cell lung can-cer (NSCLC). Oncology Journal, Brain Tumors, Lung Cancer. ABSTRACT: Small cell lung cancer (SCLC) accounts for approximately 20 of all cases of lung cancer.43. Lee JS, Murphy WK, Glisson BS, et al: Primary chemotherapy of brain metastasis in small cell lung cancer. Key words: Chemokines, cytokines, angiogenesis, inflammation, non-small cell lung cancer.It is also known that in breast and prostate cancer, the CCL2/CCR2 axis mediates metastasis to bone and lung tissue [76]. At diagnosis, the majority of non-small cell lung cancer (NSCLC) patients present with advanced disease, and even when diagnosed at anA similar observation was made in a breast cancer lung metastasis model, where neither AMD3100, nor knock-down of. CXCR4 led to increased survival [29]. Nuclear expression of CXCR4 in tumor cells of nonsmall cell lung cancer is correlated CXCL12/CXCR4 axis as a target for immune intervention with lymph node metastasis. Hum Pathol. 200839:1751-5. in the treatment of NSCLC. In patients with colorectal cancer76 and melanoma,74 CXCR4 expression of primary tumor cells correlates with recurrence, metastasis, and survival.Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the CXCR4/CXCL12 Axis in Non Small Cell Lung Cancer (NSCLC) Pathologic Roles and Therapeutic Potential.Similarly, Chen et al have found that high-level of cytomembranous CXCR4 expression correlated with brain-specific metastasis in single station M1 NSCLC patients (45). Synchronous or metachronous brain metastases (BMs) occur in about 33 of patients affected by non-small-cell lung cancer (NSCLC). To date, no reliable biological marker is able to identify patients who will develop BMs. In the present study, using a quantitative Current prognostic criteria for patients with non-small cell lung cancer are gradually enriched by the discovery of critical biological markers in surgical samples to better stratify patients with high risk for recurrent and metastatic disease after surgical manipulation. To assess the role of SDF-1/CXCR4 in metastasis, bone metastases were established by administering CaP cells into the left cardiacSDF-1 levels were highest in the pelvis, tibia, femur, liver, and adrenal/kidneys compared with the lungs, tongue, and eye, suggesting a selective effect. One of the most commonly diagnosed cancers is non-small cell lung cancer ( NSCLC), which is the leading cause of lung cancer related deaths[19] Takanami I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int.J.Cancer 2003105:186-189. Keywords: Chemokines, cytokines, angiogenesis, inflammation, non-small cell lung cancer.It is also known that in breast and prostate cancer, the CCL2/CCR2 axis mediates metastasis to bone and lung tissue [76]. This axis facilitates tumor metastasis in breast cancer, non-small cell lung cancer, rhabdomyosarcoma, and other human malignant tumors, and the blocking of CXCL12-CXCR4 biological axis inhibits metastasis [811]. Cytokeratin 19 has been described in the serum of patients with non-small cell lung cancer (NSCLC), and hasMller and colleagues provided initial evidence linking CXCL12/CXCR4 biological axis to breast cancer metastasis to specific organs [16], which was confirmed in non-small lung cancer [20]. We herein aimed to investigate the role of the axis of chemokine SDF-1 and its receptor CXCR4 in the invasion and metastasis of lung cancer. Methods: Sixty clinical non-small cell lung cancer (NSCLC) tissue samples were collected. The CXCR4 expressions in cancer CXCR4/CXCL12 in non-small-cell lung cancer metastasis to the brain.

Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer. High-level CXCR4 expression correlates with brain-specif-ic metastasis of non-small cell lung cancer. World J Surg 2011 35: 56-61. [5] Mlik-Parsadaniantz S, Rostne W. Chemo-kines and neuromodulation. Chemokines have been implicated as key contributors of non-small cell lung cancer (NSCLC) metastasis. However, the role of CXCR7, a recently discovered receptor for CXCL12 ligand, in the pathogenesis of NSCLC is unknown. Metastasis, migration and spread of cancerous cells from a tumour to distant sites in the body, resulting in the development of secondary tumours.Lung cancers may metastasize to the adrenal glands or other organs and tissues, such as the brain or bones. BACKGROUND: Brain-specific metastasis occurs frequently in lung cancer, and the mechanism is still unclear. The present study was designed to investigate the correlation between CXCR4 expression and brain-specific metastasis of non-small cell lung cancer. Dissemination of lung cancer in the thoracic cavity and metastatic spread to the liver, bone and brain are charac-teristic of non-small cell lung cancer (NSCLC), constituting the primary source of morbidity and mortality in lung cancer.

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